We Tested Wrinkle-Filler Serums to Find 10 That Really Work (2024)

This serum should be applied only where you need it, like between the brows, on smile lines, or on the forehead. The blend of hyaluronic acid and peptides helps to immediately plump lines, with a clinical test showing 45 percent fewer visible wrinkles in just four hours.

One customer review says: "This stuff is a game-changer for anyone looking to tackle fine lines and wrinkles. Packed with hyaluronic acid, it delivers a serious dose of hydration that leaves your skin feeling plump and smooth. The lightweight formula absorbs quickly, so it doesn’t feel heavy or greasy, making it a breeze to layer under makeup. After using It regularly, i have notice my skin looks fresher and more radiant. While it’s definitely a splurge, the results make it worth every penny if you’re serious about your skincare." —BC2711

With this affordable drugstore serum, you'll see immediate and long-term results. "The research done behind the product shows results in as little as two weeks, with continued results with ongoing use," says Hartman. Its key ingredients are retinol and hyaluronic acid, which work together to keep the skin smooth and hydrated.

One customer review says: "I saw results after 2 weeks. I used to have two deep vertical wrinkles between my eyebrows, and they’re almost invisible now. It’s very hydrating and smooth. Highly recommend this product!" —Rach

Using Shiseido's proprietary 'rapid pure retinol technology,' this treatment helps lessen the appearance of deep wrinkles and boost overall skin firmness and elasticity. "It’s a good product to use as a spot treatment in the most concerning areas of the face," says Hartman.

One customer review says: "Fabulous product. You just need a tiny bit and it goes a long long way. I am very happy with the Shiseido products. My dermatologist is also very happy. She has said to me 'Your skin looks great! Keep doing what you are doing!' And I will." —Betsy

Obagi's Filler Concentrate has a precision-tip applicator to preventatively target specific areas, including forehead lines, brow lines, crow’s feet, laugh lines, and fine lines around the lips. Instead of retinol, it includes Acetyl Hexapeptide-1, a biomimetic peptide used for its wrinkle-smoothing and re-plumping action.

One customer review says: "As a 30-year-old navigating the world of skincare, I was thrilled to try this out, especially since I don’t do Botox or fillers because of my fear of needles. What I appreciate most is that it’s fragrance-free, which is a win for my sensitive skin. I noticed my skin looked plumper and started glowing almost immediately after using it!" —Vanessa

This formula uses three forms of hyaluronic acid to deliver deep, long-lasting hydration and an instant plumping effect. At the same time, ingredients like copper peptides help promote collagen production and support a firmer appearance over time. Arizona-based esthetician Emme Diane Burg recommends it with a caveat: "Despite this being called a moisturizer, it lacks the richer emollients or occlusive ingredients that lock in moisture, so I’d recommend layering a more traditional moisturizer on top," she says.

One customer review says: "The best serum out there - light and buttery soft. I’ve been using it for years- no need for Botox!" —Amy T.

Along with collagen amino acids that instantly boost the skin’s volume, this serum includes vitamin C to address age spots and Omega 3s to improve hydration levels and skin suppleness.

One customer review says: "I have used this for several years with very good results. My face and chest are wrinkle free." —Jan L.

This cream uses neuropeptides to help relax facial muscles and visibly smooth fine lines. It is "perfect for a quick, visible softening without needles," says Diane Burg.

One customer review says: "I am all about aging gracefully, but using topical creams is all good. This stuff is incredible. [It] erases wrinkles, especially around the eyes and forehead. It also has a delicious cooling effect when you apply it. Don't walk, run, and buy this." —Benjamin

This serum also has a precision applicator for targeted treatment of lines on the skin, specifically around the eyes and mouth.

One customer review says: "I’ve been using this serum for a few years every morning. I use it sparingly only above my top lip and my old smokers lines have nearly disappeared. I’ll use this serum forever!" —Leyla

If you're looking for an all-over hydrator, this lightweight gel is like a drink of water for your skin. "It’s packed with a cocktail of powerful humectants that deeply hydrate, giving the skin an instant plumpness that lasts all day," says Diane Burg.

One customer review says: "It goes on so smoothly, plumps up and hydrates dry skin, and makes such a smooth surface for makeup after my skincare routine. Don't go without this product!" —Michelle

This smart serum combines three technologies to help smooth wrinkles: a neuropeptide complex, polysaccharides to plump and hydrate, and a toning marine ferment to boost firmness. It's effective, too: 87 percent of women saw smoother skin and a de-creasing effect after seven days.

One customer review says: "I was pretty skeptical when I bought this but it actually works. You can feel it immediately ... feels so good and you see the difference. Try it!" —Gripper

• Corey L. Hartman, M.D., F.A.A.D., is a board-certified dermatologist and the founder of Skin Wellness Dermatology in Birmingham, Alabama.

• Emme Diane Burg is a licensed esthetician and CEO of Emme Diane Skincare.